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Article

High response rate to PD-1 blockade in desmoplastic melanomas.

Nature - 18 Jan 2018

Eroglu Zeynep, Zaretsky Jesse M, Hu-Lieskovan Siwen, Kim Dae Won, Algazi Alain, Johnson Douglas B, Liniker Elizabeth, Ben Kong, Munhoz Rodrigo, Rapisuwon Suthee, Gherardini Pier Federico, Chmielowski Bartosz, Wang Xiaoyan, Shintaku I Peter, Wei Cody, Sosman Jeffrey A, Joseph Richard W, Postow Michael A, Carlino Matteo S, Hwu Wen-Jen, Scolyer Richard A, Messina Jane, Cochran Alistair J, Long Georgina V, Ribas Antoni

Abstract excerpt

Desmoplastic melanoma is a rare subtype of melanoma characterized by dense fibrous stroma, resistance to chemotherapy and a lack of actionable driver mutations, and is highly associated with ultraviolet light-induced DNA damage. We analysed sixty patients with advanced desmoplastic melanoma who had been treated with antibodies to block programmed cell death 1 (PD-1) or PD-1 ligand (PD-L1). Objective tumour...

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Identifiers

PMID: 29320474
DOI: 10.1038/nature25187
PMCID: PMC5773412

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