Article
Genotyping Multidrug-Resistant Mycobacterium tuberculosis from Primary Sputum and Decontaminated Sediment with an Integrated Microfluidic Amplification Microarray Test.
Journal of clinical microbiology - 1 Mar 2018
Linger Yvonne, Knickerbocker Christopher, Sipes David, Golova Julia, Franke Molly, Calderon Roger, Lecca Leonid, Thakore Nitu, Holmberg Rebecca, Qu Peter, Kukhtin Alexander, Murray Megan B, Cooney Christopher G, Chandler Darrell P
Abstract excerpt
There is a growing awareness that molecular diagnostics for detect-to-treat applications will soon need a highly multiplexed mutation detection and identification capability. In this study, we converted an open-amplicon microarray hybridization test for multidrug-resistant (MDR) Mycobacterium tuberculosis into an entirely closed-amplicon consumable (an amplification microarray) and evaluated its performance with...
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