Article
Conversion of functionally undefined homopentameric protein PbaA into a proteasome activator by mutational modification of its C-terminal segment conformation.
Protein engineering, design & selection : PEDS - 1 Jan 2018
Yagi-Utsumi Maho, Sikdar Arunima, Kozai Toshiya, Inoue Rintaro, Sugiyama Masaaki, Uchihashi Takayuki, Yagi Hirokazu, Satoh Tadashi, Kato Koichi
Abstract excerpt
Recent bioinformatic analyses identified proteasome assembly chaperone-like proteins, PbaA and PbaB, in archaea. PbaB forms a homotetramer and functions as a proteasome activator, whereas PbaA does not interact with the proteasome despite the presence of an apparent C-terminal proteasome activation motif. We revealed that PbaA forms a homopentamer predominantly in the closed conformation with its C-terminal...
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