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Small molecule GL-V9 protects against colitis-associated colorectal cancer by limiting NLRP3 inflammasome through autophagy

11 Sept 2017

Abstract excerpt

Emerging evidence suggests that NLRP3 inflammasome provides a link between colitis-associated colorectal cancer and inflammatory bowel diseases. Autophagy is induced in macrophages by AMPK activation and regulates NLRP3 inflammasome to maintain intracellular homeostasis. Here we report that a small-molecule AMPK activator (GL-V9) exerts potent anti-inflammatory effects on macrophages in vitro and in vivo, which...

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Share to Adenosine and Purinergic Signaling
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PMID: 29296531
DOI: 10.1080/2162402x.2017.1375640

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