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Article

Purine nucleotide metabolism regulates expression of the human immune ligand MICA

26 Dec 2017

Abstract excerpt

Expression of the cell-surface glycoprotein MHC class I polypeptide-related sequence A (MICA) is induced in dangerous, abnormal, or "stressed" cells, including cancer cells, virus-infected cells, and rapidly proliferating cells. MICA is recognized by the activating immune cell receptor natural killer group 2D (NKG2D), providing a mechanism by which immune cells can identify and potentially eliminate pathological...

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PMID: 29279329
DOI: 10.1074/jbc.m117.809459

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