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Article

Hippocampal Transcriptomic Profiles: Subfield Vulnerability to Age and Cognitive Impairment

7 Dec 2017

Abstract excerpt

The current study employed next-generation RNA sequencing to examine gene expression differences related to brain aging, cognitive decline, and hippocampal subfields. Young and aged rats were trained on a spatial episodic memory task. Hippocampal regions CA1, CA3, and the dentate gyrus were isolated. Poly-A mRNA was examined using two different sequencing platforms, Illumina and Ion Proton. The Illumina platform...

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PMID: 29276487
DOI: 10.3389/fnagi.2017.00383

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