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Article

Downregulation of decidual SP1 and P300 is associated with severe preeclampsia

22 Dec 2017

Abstract excerpt

Preeclampsia (PE) is a pregnancy-induced disorder characterized by hypertension and proteinuria after 20 weeks of gestation, affecting 5–7% of pregnancies worldwide. So far, the etiology of PE remains poorly understood. Abnormal decidualization is thought to contribute to the development of PE. SP1 belongs to the Sp/KLF superfamily and can recruit P300 to regulate the transcription of several genes. SP1 is also...

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PMID: 29273682
DOI: 10.1530/jme-17-0180

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