Article

Metagenomic and single-cell RNA-seq survey of the H. pylori-infected stomach in asymptomatic individuals

2021-12-05

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Objective</h4> Helicobacter pylori colonization of the gastric niche can persist for years in asymptomatic individuals. Although latent H. pylori infection can progress to cancer, a detailed survey of the microbiome and immune composition in the chronically infected stomach is still lacking. <h4>Design</h4> We collected human gastric tissues and performed metagenomic sequencing, single-cell R...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a01799df-543c-5c50-b33a-505354ba0524
DOI: 10.1101/2021.12.04.21267139

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Metagenomic and single-cell RNA-seq survey of the H. pylori-infected stomach in asymptomatic individualsDOI 10.1101/2021.12.04.21267139Read

Metagenomic and single-cell RNA-Seq survey of the Helicobacter pylori–infected stomach in asymptomatic individualsSemantic proximity Read

Single-cell RNA sequencing dissects the immunosuppressive signatures in Helicobacter pylori-infected human gastric ecosystemSemantic proximity Read

Single-cell RNA sequencing revealed the T cell heterogeneity and exhaustion subsets of Helicobacter pylori-induced gastritis - cancer transformationSemantic proximity Read

Molecular Characterization of the Human Stomach Microbiota in Gastric Cancer PatientsSemantic proximity Read

Single-cell transcriptomic profiling uncovers cellular complexity and microenvironment in gastric tumorigenesis associated with Helicobacter pyloriSemantic proximity Read

Longer survival of Helicobacter pylori positive gastric cancer patients is associated with a more active T cell immune response as revealed by single-cell sequencingSemantic proximity Read

Helicobacter pylori regulates pro- and anti-inflammatory macrophage responses to promote bacterial survivalSemantic proximity Read

Exploring the Microbiome in Gastric Cancer: Assessing Potential Implications and Contextualizing Microorganisms beyond H. pylori and Epstein-Barr VirusSemantic proximity Read

Natural history and epidemiology of <i>Helicobacter pylori</i> infectionSemantic proximity Read

Genomic diversity of Helicobacter pylori populations from different regions of the human stomachSemantic proximity Read

<i>Helicobacter pylori</i> diversification during chronic infection within a single host generates sub-populations with distinct phenotypesSemantic proximity Read

Single-cell transcriptomic profiling uncovers cellular complexity and microenvironment in gastric tumorigenesis associated with Helicobacter pyloriSemantic proximity Read