Article
Evolutionary Proteomics Uncovers Ancient Associations of Cilia with Signaling Pathways.
Developmental cell - 18 Dec 2017
Sigg Monika Abedin, Menchen Tabea, Lee Chanjae, Johnson Jeffery, Jungnickel Melissa K, Choksi Semil P, Garcia Galo, Busengdal Henriette, Dougherty Gerard W, Pennekamp Petra, Werner Claudius, Rentzsch Fabian, Florman Harvey M, Krogan Nevan, Wallingford John B, Omran Heymut, Reiter Jeremy F
Abstract excerpt
Cilia are organelles specialized for movement and signaling. To infer when during evolution signaling pathways became associated with cilia, we characterized the proteomes of cilia from sea urchins, sea anemones, and choanoflagellates. We identified 437 high-confidence ciliary candidate proteins conserved in mammals and discovered that Hedgehog and G-protein-coupled receptor pathways were linked to cilia before...
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