Article
Polymorphisms and expression of genes encoding Argonautes 1 and 2 in autoimmune thyroid diseases.
Autoimmunity - 1 Feb 2018
Tokiyoshi Ena, Watanabe Mikio, Inoue Naoya, Hidaka Yoh, Iwatani Yoshinori
Abstract excerpt
The microRNA (miRNA) biogenesis pathway is regulated by specific proteins and enzymes, including Dicer, Drosha, DGCR8, Exportin 5 and the Argonaute (AGO) family. In this study, we investigated the AGO family, which is the primary component of RISC (RNA-induced silencing complex) and directly binds to microRNA. We examined the association of polymorphisms in AGO family genes with AGO expression and with the...
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