Article
Analysis of NRAS gain in 657 patients with melanoma and evaluation of its sensitivity to a MEK inhibitor.
European journal of cancer (Oxford, England : 1990) - 1 Jan 2018
Yan Junya, Wu Xiaowen, Yu Jiayi, Yu Huan, Xu Tianxiao, Brown Kevin M, Bai Xue, Dai Jie, Ma Meng, Tang Huan, Si Lu, Chi Zhihong, Sheng Xinan, Cui Chuanliang, Kong Yan, Guo Jun
Abstract excerpt
BACKGROUND: Neuroblastoma rat-sarcoma (NRAS) mutations have been described in Chinese patients with melanoma. However, the status and the clinical significance of NRAS gain have not been investigated on a large scale. METHODS: A total of 657 melanoma samples were included in the study. NRAS copy number was examined using the QuantiGene Plex DNA assay. The sensitivities of cell lines and patient-derived xenograft...
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