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Article

Oxymatrine inhibits non-small cell lung cancer via suppression of EGFR signaling pathway.

Cancer medicine - 1 Jan 2018

Li Wei, Yu Xinfang, Tan Shiming, Liu Wenbin, Zhou Li, Liu Haidan

Abstract excerpt

Epidermal growth factor receptor (EGFR) plays a crucial role in human non-small cell lung cancer (NSCLC) tumorigenesis. In this study, oxymatrine was identified as an EGFR signaling pathway inhibitor in NSCLC. Oxymatrine inhibited anchorage-dependent and independent growth of NSCLC cell lines but had no cytotoxicity in normal lung cells. We found that exposure to oxymatrine not only suppressed the activity of...

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Identifiers

PMID: 29239135
DOI: 10.1002/cam4.1269
PMCID: PMC5773973

Genes

EGFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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