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Article

Inhibitory effect of 1,4,5,6-tetrahydroxy-7,8-diprenylxanthone against NSCLC with L858R/T790M/C797S mutant EGFR.

Scientific reports - 4 Nov 2024

Wang Jing, Wang Yuna, Zhang Shuanggou, Qu Yana, Zhang Ruohan, Wang Xuanjun, Sheng Jun, Sun Peiyuan

Abstract excerpt

Epidermal growth factor receptor (EGFR)-activating mutations are critical factors in the development of EGFR-driven non-small-cell lung cancer (NSCLC), and molecular targeted therapies have focused on inhibiting these mutations. EGFR tyrosine kinase inhibitors (TKIs) have remarkable inhibitory effects on NSCLC with EGFR mutations. However, acquired resistance limits the clinical application of EGFR-TKIs,...

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Identifiers

PMID: 39489821
DOI: 10.1038/s41598-024-78146-3
PMCID: PMC11532358

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