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Article

Restoration of glycoprotein Erns dimerization via pseudoreversion partially restores virulence of classical swine fever virus.

The Journal of general virology - 1 Jan 2018

Tucakov Anna Katharina, Yavuz Sabine, Schürmann Eva-Maria, Mischler Manjula, Klingebeil Anne, Meyers Gregor

Abstract excerpt

The classical swine fever virus (CSFV) represents one of the most important pathogens of swine. The CSFV glycoprotein Erns is an essential structural protein and an important virulence factor. The latter is dependent on the RNase activity of this envelope protein and, most likely, its secretion from the infected cell. A further important feature with regard to its function as a virulence factor is the formation...

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PMID: 29235980
DOI: 10.1099/jgv.0.000990

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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