Classical Swine Fever Virus E ^rns Deletion Mutants: <i>trans</i> -Complementation and Potential Use as Nontransmissible, Modified, Live-Attenuated Marker Vaccines

Abstract excerpt

An SK6 cell line (SK6c26) which constitutively expressed the glycoprotein E(rns) of classical swine fever virus (CSFV) was used to rescue CSFV E(rns) deletion mutants based on the infectious copy of CSFV strain C. The biochemical properties of E(rns) from this cell line were indistinguishable from those of CSFV E(rns). Two E(rns) deletion mutants were constructed, virus Flc23 and virus Flc22. Virus Flc23 encoded...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Animal Disease Management and Epidemiology
• Share to Vector-Borne Animal Diseases
• Share to Viral Infections and Immunology Research