Article
The impact of HLA-G, LILRB1 and LILRB2 gene polymorphisms on susceptibility to and severity of endometriosis.
Molecular genetics and genomics : MGG - 1 Jun 2018
Bylińska Aleksandra, Wilczyńska Karolina, Malejczyk Jacek, Milewski Łukasz, Wagner Marta, Jasek Monika, Niepiekło-Miniewska Wanda, Wiśniewski Andrzej, Płoski Rafał, Barcz Ewa, Roszkowski Piotr, Kamiński Paweł, Malinowski Andrzej, Wilczyński Jacek R, Radwan Paweł, Radwan Michał, Kuśnierczyk Piotr, Nowak Izabela
Abstract excerpt
Endometriosis is a disease in which endometriotic tissue occurs outside the uterus. Its pathogenesis is still unknown. The most widespread hypothesis claims that ectopic endometrium appears as a result of retrograde menstruation and its insufficient elimination by immunocytes. Some reports have shown expression of non-classical HLA-G molecules on ectopic endometrium. HLA-G is recognized by KIR2DL4, LILRB1 and...
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