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Immortalization of canine adipose‐derived mesenchymal stem cells and their seminiferous tubule transplantation

12 Dec 2017

Abstract excerpt

Adipose-derived mesenchymal stem cells (ADSCs) are proven to provide good effects in numerous tissue engineering application and other cell-based therapies. However, the difficulty in the proliferation of ADSCs, known as the "Hayflick limit" in vitro, limits their clinical application. Here, we immortalized canine ADSCs (cADSCs) with SV40 gene and transplanted them into busulfan-induced seminiferous tubules of...

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PMID: 29231997
DOI: 10.1002/jcb.26574

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