LEFTY2 inhibits endometrial receptivity by downregulating Orai1 expression and store-operated Ca2+ entry

Abstract excerpt

A transient window of uterine receptivity ensures that embryos implant in an optimal endometrial environment [ 1 ]. Failure to establish [ 2 ] or premature closure [ 1 , 3 , 4 ] of the implantation window is thought to be a major cause of infertility, which affects ~ 15% of couples. Conversely, prolonged receptivity may lead to out-of-phase implantation and miscarriage [ 3 , 4 ] or recurrent pregnancy loss [ 1 ,...

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