Article
Genomic variants in the FTO gene are associated with sporadic amyotrophic lateral sclerosis in Greek patients.
Human genomics - 8 Dec 2017
Mitropoulos Konstantinos, Merkouri Papadima Eleni, Xiromerisiou Georgia, Balasopoulou Angeliki, Charalampidou Kyriaki, Galani Vasiliki, Zafeiri Krystallia-Vassiliki, Dardiotis Efthymios, Ralli Styliani, Deretzi Georgia, John Anne, Kydonopoulou Kyriaki, Papadopoulou Elpida, di Pardo Alba, Akcimen Fulya, Loizedda Annalisa, Dobričić Valerija, Novaković Ivana, Kostić Vladimir S, Mizzi Clint, Peters Brock A, Basak Nazli, Orrù Sandro, Kiskinis Evangelos, Cooper David N, Gerou Spyridon, Drmanac Radoje, Bartsakoulia Marina, Tsermpini Evangelia-Eirini, Hadjigeorgiou Georgios M, Ali Bassam R, Katsila Theodora, Patrinos George P
Abstract excerpt
BACKGROUND: Amyotrophic lateral sclerosis (ALS) is a devastating disease whose complex pathology has been associated with a strong genetic component in the context of both familial and sporadic disease. Herein, we adopted a next-generation sequencing approach to Greek patients suffering from sporadic ALS (together with their healthy counterparts) in order to explore further the genetic basis of sporadic ALS...
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