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Article

Hemorrhage of liver and bone metastases as a result of rapid response to dual BRAF/MEK inhibition in metastatic melanoma: a case report.

Melanoma research - 1 Apr 2018

Loyson Tine, Werbrouck Emilie, Punie Kevin, Bonne Lawrence, Vandecaveye Vincent, Bechter Oliver

Abstract excerpt

Combination therapy using a BRAF and MEK inhibitor significantly improves both progression-free and overall survival in patients with BRAF V600-mutated stage IV melanoma. Dual MAPK inhibition achieves an objective response in the majority of patients. We present a case of a woman with BRAF V600E-mutated malignant melanoma and rapidly progressing liver, bone, and lymph node metastases. The patient commenced...

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PMID: 29215399
DOI: 10.1097/CMR.0000000000000419

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BRAF

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