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Article

Radiation necrosis mimicking rapid intracranial progression of melanoma metastasis in two patients treated with vemurafenib.

Melanoma research - 1 Apr 2014

Liebner David A, Walston Steven A, Cavaliere Robert, Powers Ciaran J, Sauvageau Eric, Lehman Norman L, Wayne Slone Hasel, Xu-Welliver Meng, Xia Fen, Kendra Kari L

Abstract excerpt

Optimal treatment of metastases to the central nervous system (CNS) in patients with malignant melanoma remains a clinical challenge. In particular, for patients with BRAF-mutant melanoma and CNS metastases, much remains unknown about the safety and efficacy of the novel BRAF-targeted agents when administered in close sequence with radiation. We report two cases of rapid development of CNS radiation necrosis in...

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Identifiers

PMID: 24407165
DOI: 10.1097/CMR.0000000000000044
PMCID: PMC4372136

Genes

BRAF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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