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Article

Disruption of an RNA-binding hinge region abolishes LHP1-mediated epigenetic repression.

Genes & development - 1 Nov 2017

Berry Scott, Rosa Stefanie, Howard Martin, Bühler Marc, Dean Caroline

Abstract excerpt

Epigenetic maintenance of gene repression is essential for development. Polycomb complexes are central to this memory, but many aspects of the underlying mechanism remain unclear. LIKE HETEROCHROMATIN PROTEIN 1 (LHP1) binds Polycomb-deposited H3K27me3 and is required for repression of many Polycomb target genes in Arabidopsis Here we show that LHP1 binds RNA in vitro through the intrinsically disordered hinge...

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Identifiers

PMID: 29212661
DOI: 10.1101/gad.305227.117
PMCID: PMC5749160

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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