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Article

On the impact of relatedness on SNP association analysis.

BMC genetics - 6 Dec 2017

Gross Arnd, Tönjes Anke, Scholz Markus

Abstract excerpt

BACKGROUND: When testing for SNP (single nucleotide polymorphism) associations in related individuals, observations are not independent. Simple linear regression assuming independent normally distributed residuals results in an increased type I error and the power of the test is also affected in a more complicate manner. Inflation of type I error is often successfully corrected by genomic control. However, this...

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Identifiers

PMID: 29212447
DOI: 10.1186/s12863-017-0571-x
PMCID: PMC5719591

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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