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Article

Age-dependent cognitive dysfunction in untreated hereditary transthyretin amyloidosis.

Journal of neurology - 1 Feb 2018

Martins da Silva Ana, Cavaco Sara, Fernandes Joana, Samões Raquel, Alves Cristina, Cardoso Márcio, Kelly Jeffery W, Monteiro Cecília, Coelho Teresa

Abstract excerpt

Central nervous system (CNS) involvement in hereditary transthyretin (TTR) amyloidosis has been described in patients whose disease course was modified by liver transplant. However, cognitive dysfunction has yet to be investigated in those patients. Moreover, CNS involvement in untreated patients or asymptomatic mutation carriers remains to be studied. A series of 340 carriers of the TTRVal30Met mutation (180...

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Source

Identifiers

PMID: 29209781
DOI: 10.1007/s00415-017-8668-8

Genes

TTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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