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Article

Rho GTPase effectors and NAD metabolism in cancer immune suppression

6 Dec 2017

Abstract excerpt

INTRODUCTION: Sustained proliferative signaling and de-regulated cellular bioenergetics are two of the chief hallmarks of cancer. Alterations in the Ras pathway and its downstream effectors are among the major drivers for uncontrolled cell growth in many cancers. The GTPases are one of the signaling molecules that activate crucial signal transducing pathways downstream of Ras through several effector proteins....

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PMID: 29207896
DOI: 10.1080/14728222.2018.1413091

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