Article
Choice of surrogate tissue influences neonatal EWAS findings.
BMC medicine - 5 Dec 2017
Lin Xinyi, Teh Ai Ling, Chen Li, Lim Ives Yubin, Tan Pei Fang, MacIsaac Julia L, Morin Alexander M, Yap Fabian, Tan Kok Hian, Saw Seang Mei, Lee Yung Seng, Holbrook Joanna D, Godfrey Keith M, Meaney Michael J, Kobor Michael S, Chong Yap Seng, Gluckman Peter D, Karnani Neerja
Abstract excerpt
BACKGROUND: Epigenomes are tissue specific and thus the choice of surrogate tissue can play a critical role in interpreting neonatal epigenome-wide association studies (EWAS) and in their extrapolation to target tissue. To develop a better understanding of the link between tissue specificity and neonatal EWAS, and the contributions of genotype and prenatal factors, we compared genome-wide DNA methylation of cord...
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