Article
Identification of coexistence of BRAF V600E mutation and EZH2 gain specifically in melanoma as a promising target for combination therapy.
Journal of translational medicine - 4 Dec 2017
Yu Huan, Ma Meng, Yan Junya, Xu Longwen, Yu Jiayi, Dai Jie, Xu Tianxiao, Tang Huan, Wu Xiaowen, Li Siming, Lian Bin, Mao Lili, Chi Zhihong, Cui Chuanliang, Guo Jun, Kong Yan
Abstract excerpt
BACKGROUND: Coexistence of enhancer of zeste homolog 2 (EZH2) and BRAF gene aberrations has been described in many cancer types. In this study, we aim to explore the coexistence status of BRAF V600E mutation and the copy number variation of EZH2 and explore the potential of this combination as a therapeutic target. METHODS: A total of 138 cases of melanoma samples harboring BRAF V600E mutation were included, and...
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