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Article

Preliminary Evidence for an Association Between Variants of the Catechol-O-Methyltransferase (COMT) Gene and Premature Ejaculation.

The journal of sexual medicine - 1 Dec 2017

Jern Patrick, Johansson Ada, Strohmaier Jana, Treutlein Jens, Piha Juhana, Rietschel Marcella

Abstract excerpt

BACKGROUND: Studies have suggested that dopamine plays a role in the neurobiological mechanism that triggers ejaculation, leading scientists to hypothesize that dopamine-related genetic polymorphisms could contribute to symptoms of premature ejaculation (PE). AIM: To investigate associations between dopamine receptor and catechol-O-methyltransferase (COMT; an enzyme involved in the catabolism of dopamine)...

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Source

Identifiers

PMID: 29198511
DOI: 10.1016/j.jsxm.2017.11.002

Genes

COMT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

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Research trail→

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Preliminary Evidence for an Association Between Variants of the Catechol-O-Methyltransferase (COMT) Gene and Premature Ejaculation.PMID 29198511Read ↗

Relationship between premature ejaculation and genetic polymorphisms of the dopamine transporter gene (SLC6A3).Semantic proximity Read ↗

Catechol-O-methyltransferase (COMT): a gene contributing to sex differences in brain function, and to sexual dimorphism in the predisposition to psychiatric disorders.Semantic proximity Read ↗

Single nucleotide polymorphisms in 5-HT receptors in the etiology of premature ejaculation.Semantic proximity Read ↗

Effects of CYP24A1 polymorphisms on premature ejaculation: a case-control study.Semantic proximity Read ↗

The dopamine transporter gene (DAT1) polymorphism is associated with premature ejaculation.Semantic proximity Read ↗

Importance of the COMT gene for sex differences in brain function and predisposition to psychiatric disorders.Semantic proximity Read ↗

A meta-analysis of the effects of the 5-hydroxytryptamine transporter gene-linked promoter region polymorphism on susceptibility to lifelong premature ejaculation.Semantic proximity Read ↗

Catechol-O-methyltransferase contributes to genetic susceptibility shared among anxiety spectrum phenotypes.Semantic proximity Read ↗

Are single nucleotide polymorphisms in the oxytocin and vasopressin 1A/1B receptor genes likely candidates for variation in ejaculatory function?Semantic proximity Read ↗

Analysis of the Association between Catechol-O-Methyltransferase Val158Met and Male Sexual Orientation.Semantic proximity Read ↗

Genetic variation in catechol-O-methyltransferase (COMT) and obesity in the prostate, lung, colorectal, and ovarian (PLCO) cancer screening trial.Semantic proximity Read ↗

Comprehensive interrogation of CpG island methylation in the gene encoding COMT, a key estrogen and catecholamine regulatorSemantic proximity Read ↗

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