Article
Histone profiling reveals the H1.3 histone variant as a prognostic biomarker for pancreatic ductal adenocarcinoma.
BMC cancer - 2 Dec 2017
Bauden Monika, Kristl Theresa, Sasor Agata, Andersson Bodil, Marko-Varga György, Andersson Roland, Ansari Daniel
Abstract excerpt
BACKGROUND: Epigenetic alterations have been recognized as important contributors to the pathogenesis of PDAC. However, the role of histone variants in pancreatic tumor progression is still not completely understood. The aim of this study was to explore the expression and prognostic significance of histone protein variants in PDAC patients. METHODS: Liquid chromatography-tandem mass spectrometry (LC-MS/MS) was...
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