Article
In Situ Multiplexing to Identify, Quantify, and Phenotype the HIV-1/SIV Reservoir Within Lymphoid Tissue.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2022
Busman-Sahay Kathleen, Nekorchuk Michael D, Starke Carly Elizabeth, Chan Chi Ngai, Estes Jacob D
Abstract excerpt
Modern combination antiretroviral therapy (ART) regimens provide abiding viral suppression for most individuals infected with human immunodeficiency virus (HIV). However, the persistence of viral reservoirs ensures that eradication of HIV-1 (i.e., cure) or sustained ART-free remission (i.e., functional cure) remains elusive, necessitating continual, strict ART adherence and contributing to HIV-1-related...
Topics
- Animals
- CD4-Positive T-Lymphocytes
- HIV Infections
- HIV-1
- Lymphoid Tissue
- Macaca mulatta
- Phenotype
- Simian Acquired Immunodeficiency Syndrome
- Simian Immunodeficiency Virus
- Viral Load