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Article

Impaired neurogenesis and associated gliosis in mouse brain with PEX13 deficiency.

Molecular and cellular neurosciences - 1 Apr 2018

Rahim Rani Sadia, St John James A, Crane Denis I, Meedeniya Adrian C B

Abstract excerpt

Zellweger syndrome (ZS), a neonatal lethal disorder arising from defective peroxisome biogenesis, features profound neuroanatomical abnormalities and brain dysfunction. Here we used mice with brain-restricted inactivation of the peroxisome biogenesis gene PEX13 to model the pathophysiological features of ZS, and determine the impact of peroxisome dysfunction on neurogenesis and cell maturation in ZS. In the...

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Source

Identifiers

PMID: 29187321
DOI: 10.1016/j.mcn.2017.11.015

Genes

PEX13

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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