Article
Systems genetics identifies a role for Cacna2d1 regulation in elevated intraocular pressure and glaucoma susceptibility.
Nature communications - 24 Nov 2017
Chintalapudi Sumana R, Maria Doaa, Di Wang Xiang, Bailey Jessica N Cooke, Hysi Pirro G, Wiggs Janey L, Williams Robert W, Jablonski Monica M
Abstract excerpt
Glaucoma is a multi-factorial blinding disease in which genetic factors play an important role. Elevated intraocular pressure is a highly heritable risk factor for primary open angle glaucoma and currently the only target for glaucoma therapy. Our study helps to better understand underlying genetic and molecular mechanisms that regulate intraocular pressure, and identifies a new candidate gene, Cacna2d1, that...
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