Article
Efficacy and safety of percutaneous administration of dihydrotestosterone in children of different genetic backgrounds with micropenis.
Journal of pediatric endocrinology & metabolism : JPEM - 27 Nov 2017
Xu Dan, Lu Liangsheng, Xi Li, Cheng Ruoqian, Pei Zhou, Bi Yunli, Ruan Shuangsui, Luo Feihong
Abstract excerpt
BACKGROUND: Exogenous androgen supplement is an optional treatment for micropenis; however, its use in childhood is controversial due to potential side effects. METHODS: Twenty-three children (mean age: 4.07±3.4 years) with micropenis of unknown causes harboring the 46,XY karyotype were recruited in an open prospective study. Androgen receptor (AR), steroid 5α-reductase-2 (SRD5A2), and SRY genes were sequenced;...
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