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Article

Phosphoprotein DIGE profiles reflect blast differentiation, cytogenetic risk stratification, FLT3/NPM1 mutations and therapy response in acute myeloid leukaemia.

Journal of proteomics - 20 Feb 2018

Forthun Rakel Brendsdal, Aasebø Elise, Rasinger Josef Daniel, Bedringaas Siv Lise, Berven Frode, Selheim Frode, Bruserud Øystein, Gjertsen Bjørn Tore

Abstract excerpt

Acute myeloid leukaemia (AML) is an aggressive blood cancer characterized by a distinct block in differentiation of myeloid progenitors, recurrent chromosomal translocations and gene mutations of which >50% involve signal transduction through dysregulated kinases and phosphatases. In search for novel protein biomarkers for disease stratification we investigated the phosphoproteome in leukaemic cells from 62 AML...

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Source

Identifiers

PMID: 29175091
DOI: 10.1016/j.jprot.2017.11.014

Genes

NPM1
ANXA5
EFHD2
FLT3
SRM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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