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Article

Baseline and Breakthrough Resistance Mutations in HCV Patients Failing DAAs.

Scientific reports - 22 Nov 2017

Paolucci Stefania, Premoli Marta, Novati Stefano, Gulminetti Roberto, Maserati Renato, Barbarini Giorgio, Sacchi Paolo, Piralla Antonio, Sassera Davide, De Marco Leone, Girello Alessia, Mondelli Mario U, Baldanti Fausto

Abstract excerpt

Sustained virologic response rates have increased dramatically following direct acting antiviral (DAA) therapy in chronic HCV infection. However, resistance-associated substitutions (RASs) may occur either prior to DAA or following drug exposure. The aim of this study was to determine RASs in DAA treatment-failing patients and the role of RASs in failure treatment. Six hundred and twenty HCV patients were...

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Share to Antiviral Agents
Share to Drug Resistance, Viral

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genotype

Share to Hepacivirus

Share to Hepatitis C, Chronic

Share to High-Throughput Nucleotide Sequencing

Share to Sustained Virologic Response

Share to Treatment Failure

Source

Open in PubMed Open full text

Identifiers

PMID: 29167469
DOI: 10.1038/s41598-017-15987-1
PMCID: PMC5700050

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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