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Article

Repair gene O6‐methylguanine‐DNA methyltransferase is controlled by SP1 and up‐regulated by glucocorticoids, but not by temozolomide and radiation

22 Nov 2017

Abstract excerpt

Abstract Therapy of malignant glioma relies on treatment with the O6‐methylating agent temozolomide (TMZ) concomitant with ionizing radiation followed by adjuvant TMZ. For the treatment of recurrences, DNA chloroethylating drugs are also used. The main killing lesion induced by these drugs is O6‐alkylguanine. Since this damage is repaired by O6‐methylguanine‐DNA methyltransferase (MGMT), the repair enzyme...

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PMID: 29164620
DOI: 10.1111/jnc.14262

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