Article
Regulation of T helper cell responses during antigen presentation by norepinephrine-exposed endothelial cells.
Immunology - 1 May 2018
Xu Linghui, Ding Wanhong, Stohl Lori L, Zhou Xi K, Azizi Shayan, Chuang Ethan, Lam Jimmy, Wagner John A, Granstein Richard D
Abstract excerpt
Dermal blood vessels and regional lymph nodes are innervated by sympathetic nerves and, under stress, sympathetic nerves release norepinephrine (NE). Exposure of primary murine dermal microvascular endothelial cells (pDMECs) to NE followed by co-culture with Langerhans cells (LCs), responsive CD4+ T-cells and antigen resulted in modulation of CD4+ T-cell responses. NE-treatment of pDMECs induced increased...
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