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Article

Early-life-trauma triggers interferon-β resistance and neurodegeneration in a multiple sclerosis model via downregulated β1-adrenergic signaling.

Nature communications - 4 Jan 2021

Khaw Yee Ming, Majid Danish, Oh Sungjong, Kang Eunjoo, Inoue Makoto

Abstract excerpt

Environmental triggers have important functions in multiple sclerosis (MS) susceptibility, phenotype, and trajectory. Exposure to early life trauma (ELT) has been associated with higher relapse rates in MS patients; however, the underlying mechanisms are not well-defined. Here we show ELT induces mechanistic and phenotypical alterations during experimental autoimmune encephalitis (EAE). ELT sustains...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Interferon-beta

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Share to Receptors, Adrenergic, beta-1

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Source

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Identifiers

PMID: 33397973
DOI: 10.1038/s41467-020-20302-0
PMCID: PMC7782805

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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