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Article

microRNA-449a modulates medullary thymic epithelial cell differentiation.

Scientific reports - 21 Nov 2017

Chen Pengfei, Zhang Haohao, Sun Xiaohua, Hu Yiming, Jiang Wenxia, Liu Zhanjie, Liu Sanhong, Zhang Xiaoren

Abstract excerpt

Medullary thymic epithelial cells (mTECs) ectopically express a diversity of peripheral tissue-restricted antigens (PTAs) and provide unique cues for the expansion, maturation and selection of a repertoire of functionally diverse T lymphocytes. Genetic deletion of all mature microRNAs in thymic epithelial cells (TECs) results in premature thymic involution, progressive disorganisation of the thymic epithelium,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29162901
DOI: 10.1038/s41598-017-16162-2
PMCID: PMC5698406

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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