Article
MicroRNAs control the maintenance of thymic epithelia and their competence for T lineage commitment and thymocyte selection.
Journal of immunology (Baltimore, Md. : 1950) - 15 Oct 2012
Zuklys Saulius, Mayer Carlos E, Zhanybekova Saule, Stefanski Heather E, Nusspaumer Gretel, Gill Jason, Barthlott Thomas, Chappaz Stephane, Nitta Takeshi, Dooley James, Nogales-Cadenas Ruben, Takahama Yousuke, Finke Daniela, Liston Adrian, Blazar Bruce R, Pascual-Montano Alberto, Holländer Georg A
Abstract excerpt
Thymic epithelial cells provide unique cues for the lifelong selection and differentiation of a repertoire of functionally diverse T cells. Rendered microRNA (miRNA) deficient, these stromal cells in the mouse lose their capacity to instruct the commitment of hematopoietic precursors to a T cell fate, to effect thymocyte positive selection, and to achieve promiscuous gene expression required for central tolerance...
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