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Article

Precision Oncology: Between Vaguely Right and Precisely Wrong.

Cancer research - 1 Dec 2017

Brock Amy, Huang Sui

Abstract excerpt

Precision Oncology seeks to identify and target the mutation that drives a tumor. Despite its straightforward rationale, concerns about its effectiveness are mounting. What is the biological explanation for the "imprecision?" First, Precision Oncology relies on indiscriminate sequencing of genomes in biopsies that barely represent the heterogeneous mix of tumor cells. Second, findings that defy the orthodoxy of...

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Identifiers

PMID: 29162615
DOI: 10.1158/0008-5472.CAN-17-0448

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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