Article
Patient-derived iPSCs show premature neural differentiation and neuron type-specific phenotypes relevant to neurodevelopment.
Molecular psychiatry - 1 Aug 2018
Yeh E, Dao D Q, Wu Z Y, Kandalam S M, Camacho F M, Tom C, Zhang W, Krencik R, Rauen K A, Ullian E M, Weiss L A
Abstract excerpt
Ras/MAPK pathway signaling is a major participant in neurodevelopment, and evidence suggests that BRAF, a key Ras signal mediator, influences human behavior. We studied the role of the mutation BRAFQ257R, the most common cause of cardiofaciocutaneous syndrome (CFC), in an induced pluripotent stem cell (iPSC)-derived model of human neurodevelopment. In iPSC-derived neuronal cultures from CFC subjects, we observed...
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