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Article

Identification of ABC transporters acting in vitamin B12 metabolism in Caenorhabditis elegans.

Molecular genetics and metabolism - 1 Dec 2017

McDonald Megan K, Fritz Julie-Anne, Jia Dongxin, Scheuchner Deborah, Snyder Floyd F, Stanislaus Avalyn, Curle Jared, Li Liang, Stabler Sally P, Allen Robert H, Mains Paul E, Gravel Roy A

Abstract excerpt

Vitamin B12 (cobalamin, Cbl) is a micronutrient essential to human health. Cbl is not utilized as is but must go through complex subcellular and metabolic processing to generate two cofactor forms: methyl-Cbl for methionine synthase, a cytosolic enzyme; and adenosyl-Cbl for methylmalonyl-CoA mutase, a mitochondrial enzyme. Some 10-12 human genes have been identified responsible for the intracellular conversion of...

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PMID: 29153845
DOI: 10.1016/j.ymgme.2017.11.002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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