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Article

The lysosomal protein ABCD4 can transport vitamin B12 across liposomal membranes in vitro.

The Journal of biological chemistry - 1 Jan 2000

Kitai Katsuki, Kawaguchi Kosuke, Tomohiro Takenori, Morita Masashi, So Takanori, Imanaka Tsuneo

Abstract excerpt

Vitamin B12 (cobalamin) is an essential micronutrient for human health, and mutation and dysregulation of cobalamin metabolism are associated with serious diseases, such as methylmalonic aciduria and homocystinuria. Mutations in ABCD4 or LMBRD1, which encode the ABC transporter ABCD4 and lysosomal membrane protein LMBD1, respectively, lead to errors in cobalamin metabolism, with the phenotype of a failure to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33845046
DOI: 10.1016/j.jbc.2021.100654
PMCID: PMC8113721

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