Genetic association of the NQO1 rs1800566 (609C>T) variant with risk of preeclampsia in the Chinese Han population.

doi:10.1016/j.preghy.2017.05.004

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Article

Genetic association of the NQO1 rs1800566 (609C>T) variant with risk of preeclampsia in the Chinese Han population.

Pregnancy hypertension - 1 Oct 2017

Zhao Liping, Liu Jingjing, Tan Ping, Zhang Wenke, Gao Qun, Li Xueying, Lin Yan, Dong Qian, Wang Haiyan, Liu Shiguo

Abstract excerpt

AIMS: The NQO1 gene, located on chromosome 16q22, encodes NAD(P)H dehydrogenase 1, an enzyme that can reduce the production of reactive oxygen species and thereby protect cells from oxidative damage. A functional variant of NQO1, rs1800566 (c.C609T/p.Pro187Ser), has significantly less enzymatic activity. Oxidative imbalance plays an important role in the pathogenesis of preeclampsia (PE). The purpose of our study...

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PMID: 29153688
DOI: 10.1016/j.preghy.2017.05.004

Genes

NQO1

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