Article
NEAT1 acts as an inducer of cancer stem cell-like phenotypes in NSCLC by inhibiting EGCG-upregulated CTR1.
Journal of cellular physiology - 1 Jun 2018
Jiang Pan, Chen Aochang, Wu Xiaoyue, Zhou Ming, Ul Haq Ijaz, Mariyam Zahula, Feng Qing
Abstract excerpt
Long non-coding RNAs (lncRNAs) play significant roles in the pathogenesis of various cancers, including lung cancer. In this study, we aimed to investigate the biological function of lncRNA nuclear enriched abundant transcript 1 (NEAT1) in cancer stem cells (CSCs). CSCs have been suggested as the main cause of tumor metastasis, tumor recurrence, and chemotherapy resistance. The copper transporter 1 (CTR1) has...
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