Article

Functional Role of the SLC7A11-AS1/xCT Axis in the Development of Gastric Cancer Cisplatin-resistance by a GSH-dependent Mechanism

2021-05-07

Abstract excerpt

<h4>Background: </h4> Resistance to platinum-based chemotherapy is a major obstacle in gastric cancer (GC) treatment. Abundant long noncoding RNAs (lncRNAs) are reported to play important roles in tumorigenesis and drug resistance biology. We aimed to investigate the roles and mechanisms of SLC7A11-AS1 in GC cisplatin resistance. <h4>Methods: </h4>: Quantitative real-time PCR (qRT-PCR), RNA fluorescence in situ hy...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 5dde12b6-f78b-5564-8beb-54dcba117711
DOI: 10.21203/rs.3.rs-406690/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Functional Role of the SLC7A11-AS1/xCT Axis in the Development of Gastric Cancer Cisplatin-resistance by a GSH-dependent MechanismDOI 10.21203/rs.3.rs-406690/v1Read

Long Non-Coding RNA in Gastric Cancer: Mechanisms and Clinical Implications for Drug ResistanceSemantic proximity Read

Exosomal Transfer of MiR-500a-3p Confers Cisplatin Resistance and Stemness via Targeting FBXW7 in Gastric CancerSemantic proximity Read

LncRNA SNHG5 promotes cisplatin resistance in gastric cancer via inhibiting cell apoptosis.Semantic proximity Read

GSR Mediates Cisplatin Resistance in Oral Cancer by Protecting MitochondriaSemantic proximity Read

LncRNA FEZF1-AS1 Promotes Multi-Drug Resistance of Gastric Cancer Cells via Upregulating ATG5Semantic proximity Read

Portrayal of the complex molecular landscape of multidrug resistance in gastric cancer: Unveiling the potential targetsSemantic proximity Read

The role of microRNA in cisplatin resistance or sensitivitySemantic proximity Read

CircHIPK3 contributes to cisplatin resistance in gastric cancer by blocking autophagy‐dependent ferroptosisSemantic proximity Read

Establishment of panapoptotic gene signatures of platinum-chemotherapy to predict the response of chemotherapeutic drug resistance in gastric cancerSemantic proximity Read

LncRNA PROX1-AS1 Facilitates Gastric Cancer Progression via miR-877-5p/PD-L1 AxisSemantic proximity Read

TUBA1C: a new potential target of LncRNA EGFR-AS1 promotes gastric cancer progressionSemantic proximity Read

OIP5-AS1/CD147/TRPM7 axis promotes gastric cancer metastasis by regulating apoptosis related PI3K-Akt signalingSemantic proximity Read