Article
Modeling the Causal Role of DNA Methylation in the Association Between Cigarette Smoking and Inflammation in African Americans: A 2-Step Epigenetic Mendelian Randomization Study.
American journal of epidemiology - 15 Nov 2017
Jhun Min A, Smith Jennifer A, Ware Erin B, Kardia Sharon L R, Mosley Thomas H, Turner Stephen T, Peyser Patricia A, Park Sung Kyun
Abstract excerpt
The association between cigarette smoking and inflammation is well known. However, the biological mechanisms behind the association are not fully understood, particularly the role of DNA methylation, which is known to be affected by smoking. Using 2-step epigenetic Mendelian randomization, we investigated the role of DNA methylation in the association between cigarette smoking and inflammation. In 822 African...
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