Age-induced and photoinduced changes in gene expression profiles in facial skin of Caucasian females across 6 decades of age.

doi:10.1016/j.jaad.2017.09.012

Article

Age-induced and photoinduced changes in gene expression profiles in facial skin of Caucasian females across 6 decades of age.

Journal of the American Academy of Dermatology - 1 Jan 2018

Kimball Alexa B, Alora-Palli Maria B, Tamura Makio, Mullins Lisa A, Soh Chieko, Binder Robert L, Houston Neil A, Conley Emily D, Tung Joyce Y, Annunziata Nikki E, Bascom Charles C, Isfort Robert J, Jarrold Bradley B, Kainkaryam Raghu, Rocchetta Heather L, Swift Dionne D, Tiesman Jay P, Toyama Kazumi, Xu Jun, Yan Xianghong, Osborne Rosemarie

Abstract excerpt

BACKGROUND: Intrinsic and extrinsic factors, including ultraviolet irradiation, lead to visible signs of skin aging. OBJECTIVE: We evaluated molecular changes occurring in photoexposed and photoprotected skin of white women 20 to 74 years of age, some of whom appeared substantially younger than their chronologic age. METHODS: Histologic and transcriptomics profiling were conducted on skin biopsy samples of...

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Age-induced and photoinduced changes in gene expression profiles in facial skin of Caucasian females across 6 decades of age.

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