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Glioblastoma in neurofibromatosis 1 patients without IDH1, BRAF V600E, and TERT promoter mutations.

Brain tumor pathology - 1 Jan 2018

Shibahara Ichiyo, Sonoda Yukihiko, Suzuki Hiroyoshi, Mayama Akifumi, Kanamori Masayuki, Saito Ryuta, Suzuki Yasuhiro, Mashiyama Shoji, Uenohara Hiroshi, Watanabe Mika, Kumabe Toshihiro, Tominaga Teiji

Abstract excerpt

Pilocytic astrocytomas and low-grade gliomas are more common compared with glioblastomas in patients with neurofibromatosis 1 (NF1). A recent genome-wide analysis has shown frequent NF1 gene alterations in the mesenchymal subtype of a glioblastoma; however, little is known about clinicopathological features of glioblastomas in NF1 patients (NF1 glioblastomas). We analyzed four NF1 glioblastomas. Radiographical...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 29138945
DOI: 10.1007/s10014-017-0302-z

Genes

BRAF
IDH1
TERT

Variants

Provenance

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